Neurology. 2006 Aug 8;67(3):526-7.

The effect of APOE genotype on clinical phenotype in Alzheimer disease.

van der Flier WM, Schoonenboom SN, Pijnenburg YA, Fox NC, Scheltens P.

Source

Department of Neurology and Alzheimer Center, Vrije Universiteit Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands. wm.vdflier@vumc.nl

Abstract

The authors classified 100 patients with Alzheimer disease (AD) as presenting with a memory or nonmemory phenotype. APOE genotype was determined. There was an association between APOE-epsilon4 and clinical phenotype (odds ratio = 3.0; 95% CI: 1.2 to 7.8), suggesting that two subtypes of AD can be identified. The typical amnestic phenotype seems to be promoted by the APOE-epsilon4 allele, whereas the atypical nonmemory phenotype occurs in the absence of the APOE-epsilon4 allele.

Comment in

Neurology. 2007 Feb 20;68(8):624; author reply 624.

PMID:: 16894123; [PubMed - indexed for MEDLINE]

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Research Support, Non-U.S. Gov't

MeSH Terms

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Apolipoproteins E

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