Immunologic diseases, anti-inflammatory drugs, and Parkinson disease: a case-control study

Neurology. 2006 Aug 8;67(3):494-6. doi: 10.1212/01.wnl.0000227906.99570.cc.

Abstract

The authors studied the association of markers of inflammation with the later development of Parkinson disease (PD) using a case-control design (196 cases and 196 matched controls). The frequency of diseases of immediate-type hypersensitivity was significantly higher in cases than controls. In addition, cases used anti-inflammatory agents less frequently than controls (nonsignificant trend). The results may support the hypothesis that there is an inflammatory component in the pathogenesis of PD.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Aged
  • Anti-Inflammatory Agents / adverse effects
  • Anti-Inflammatory Agents / therapeutic use
  • Case-Control Studies
  • Female
  • Humans
  • Immune System Diseases
  • Inflammation / complications*
  • Inflammation / drug therapy
  • Inflammation / immunology
  • Male
  • Parkinson Disease / etiology*
  • Parkinson Disease / immunology

Substances

  • Anti-Inflammatory Agents