Behav Neurosci. 2006 Aug;120(4):873-9.

Immediate shock deficit in fear conditioning: effects of shock manipulations.

Landeira-Fernandez J, DeCola JP, Kim JJ, Fanselow MS.

Source

Departamento de Psicologia, Pontificia Universidade Catolico do Rio de Janeiro, Rio de Janeiro, Brazil. landeira@psi.puc-rio.br

Abstract

Pavlovian contextual fear conditioning occurs when an aversive unconditional stimulus (US), such as a footshock, is presented to a rat shortly after it is placed in an experimental context. Contextual fear conditioning does not occur when the shock is presented immediately upon placement of the rat in the novel chamber. In the present study, the authors report that increasing either the number of immediate shock sessions (Experiment 1) or the immediate shock duration (Experiment 2) did not reverse this deficit. However, immediate shock seems to sensitize subsequent context conditioning (Experiment 3). These findings suggest that the associative deficit produced by immediate shock is not related to the rat's ability to process the footshock US.

PMID:: 16893293; [PubMed - indexed for MEDLINE]

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R01 MH62122/MH/NIMH NIH HHS/United States

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