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1: J Korean Med Sci. 2006 Aug;21(4):758-60.Click here to read Links

Deflazacort for type-1 autoimmune hepatitis in a Korean girl.

Bae SH, Kim JS, Kim DH.

Department of Pediatrics, School of Medicine, Konkuk University, Gwangjin-gu, Seoul, Korea. baedori@hanafos.com

Prednisone or prednisolone are the mainstay drug treatments for autoimmune hepatitis in children. However, long-term use of corticosteroid is associated with the risk of steroid-induced toxicities, and this situation requires newer immuno-suppressive agents for the treatment of autoimmune hepatitis, especially in growing children. An 11-yr-old Korean girl with type-1 autoimmune hepatitis discontinued prednisolone due to toxicities, i.e., hirsutism, buffalo hump, and skin striae, and remained clinical and biochemical remission under replacement of deflazacort and ursodeoxycholic acid combination therapy. A follow-up liver biopsy after 19 months of deflazacort and ursodeoxycholic acid treatment showed histologic remission.

PMID: 16891827 [PubMed - indexed for MEDLINE]

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