Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Autoimmun Rev. 2006 Jul;5(6):414-8. Epub 2005 Dec 7.

Role of anti-DNA antibodies in the pathogenesis of lupus nephritis.

Author information

  • 1Specialized Center of Research on Systemic Lupus Erythematosus, Division of Rheumatology and Immunology, Department of Internal Medicine, University of Virginia, Charlottesville, VA 22908, USA. usd7w@virginia.edu

Abstract

Despite a good association between anti-DNA autoantibodies and lupus nephritis, it is difficult to determine the pathogenic potential of an anti-DNA autoantibody response. It is proposed that anti-DNA antibodies can exert their pathogenic effects through deposition as immune complexes in the kidney or through the recognition of cross-reactive antigens in the kidneys. Several studies in literature demonstrate that cross-reactivity of anti-DNA antibodies with kidney antigens is critical for their pathogenic potential. This raises the question whether DNA is responsible for the activation and selection of B cells generating cross-reactive anti-DNA antibodies. Recent studies suggest that antigens other than DNA can initiate an antibody response that is cross-reactive with dsDNA. Moreover, we and other have demonstrated that lupus nephritis can occur in the absence of anti-DNA antibodies. Thus, reactivity to dsDNA should be considered as one of the characteristic of polyreactive autoantibodies and not a primary requisite for the pathogenesis of lupus nephritis.

PMID:
16890896
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk