Warning: The NCBI web site requires JavaScript to function. more...

My NCBI Sign In

Lancet. 2006 Aug 5;368(9534):489-504.

HIV/AIDS epidemiology, pathogenesis, prevention, and treatment.

Simon V, Ho DD, Abdool Karim Q.

Source

Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY, USA. viviana.simon@mssm.edu

Abstract

The HIV-1 pandemic is a complex mix of diverse epidemics within and between countries and regions of the world, and is undoubtedly the defining public-health crisis of our time. Research has deepened our understanding of how the virus replicates, manipulates, and hides in an infected person. Although our understanding of pathogenesis and transmission dynamics has become more nuanced and prevention options have expanded, a cure or protective vaccine remains elusive. Antiretroviral treatment has transformed AIDS from an inevitably fatal condition to a chronic, manageable disease in some settings. This transformation has yet to be realised in those parts of the world that continue to bear a disproportionate burden of new HIV-1 infections and are most affected by increasing morbidity and mortality. This Seminar provides an update on epidemiology, pathogenesis, treatment, and prevention interventions pertinent to HIV-1.

Comment in

Lancet. 2006 Sep 23;368(9541):1064-5.

PMID:: 16890836; [PubMed - indexed for MEDLINE]
PMCID: PMC2913538

Free PMC Article

Images from this publication.See all images (6) Free text

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Supplemental Content

Click here to read

Click here to read

Related citations

Global epidemiology of HIV-AIDS. [Infect Dis Clin North Am. 2007]
Global epidemiology of HIV-AIDS.
Abdool Karim SS, Abdool Karim Q, Gouws E, Baxter C. Infect Dis Clin North Am. 2007 Mar; 21(1):1-17, vii.
Antiretroviral therapy as HIV prevention: status and prospects. [Am J Public Health. 2010]
Antiretroviral therapy as HIV prevention: status and prospects.
Mayer KH, Venkatesh KK. Am J Public Health. 2010 Oct; 100(10):1867-76. Epub 2010 Aug 19.
Review Study of the impact of HIV genotypic drug resistance testing on therapy efficacy. [Verh K Acad Geneeskd Belg. 2001]
Review Study of the impact of HIV genotypic drug resistance testing on therapy efficacy.
Van Vaerenbergh K. Verh K Acad Geneeskd Belg. 2001; 63(5):447-73.
The AIDS epidemic--a progress report from Mexico City. [N Engl J Med. 2008]
The AIDS epidemic--a progress report from Mexico City.
Steinbrook R. N Engl J Med. 2008 Aug 28; 359(9):885-7.
Review Molecular biological assessment methods and understanding the course of the HIV infection. [APMIS Suppl. 2003]
Review Molecular biological assessment methods and understanding the course of the HIV infection.
Katzenstein TL. APMIS Suppl. 2003; (114):1-37.

See reviews... See all...

Cited by 26 PubMed Central articles

Spatial visualization of multivariate datasets: an analysis of STD and HIV/AIDS diagnosis rates and socioeconomic context using ring maps. [Public Health Rep. 2011]
Spatial visualization of multivariate datasets: an analysis of STD and HIV/AIDS diagnosis rates and socioeconomic context using ring maps.
Lòpez-De Fede A, Stewart JE, Hardin JW, Mayfield-Smith K, Sudduth D. Public Health Rep. 2011 Sep-Oct; 126 Suppl 3:115-26.
Enumeration of CD4+ T-cells using a portable microchip count platform in Tanzanian HIV-infected patients. [PLoS One. 2011]
Enumeration of CD4+ T-cells using a portable microchip count platform in Tanzanian HIV-infected patients.
Moon S, Gurkan UA, Blander J, Fawzi WW, Aboud S, Mugusi F, Kuritzkes DR, Demirci U. PLoS One. 2011; 6(7):e21409. Epub 2011 Jul 6.
Identifying the age cohort responsible for transmission in a natural outbreak of Bordetella bronchiseptica. [PLoS Pathog. 2010]
Identifying the age cohort responsible for transmission in a natural outbreak of Bordetella bronchiseptica.
Long GH, Sinha D, Read AF, Pritt S, Kline B, Harvill ET, Hudson PJ, Bjørnstad ON. PLoS Pathog. 2010 Dec 16; 6(12):e1001224. Epub 2010 Dec 16.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

HIV/AIDS epidemiology, pathogenesis, prevention, and treatment.
HIV/AIDS epidemiology, pathogenesis, prevention, and treatment.
Lancet. 2006 Aug 5 ;368(9534):489-504.

PubMed
Abnormal myocardial deformation properties in obese, non-hypertensive children: ...
Abnormal myocardial deformation properties in obese, non-hypertensive children: an ambulatory blood pressure monitoring, standard echocardiographic, and strain rate imaging study.
Eur Heart J. 2006 Nov ;27(22):2689-95. Epub 2006 Aug 11 .

PubMed
Extended MRI findings of intersection syndrome.
Extended MRI findings of intersection syndrome.
Skeletal Radiol. 2009 Feb ;38(2):157-63. Epub 2008 Sep 23 .

PubMed
Up-regulation of human monocyte CD163 upon activation of cell-surface Toll-like ...
Up-regulation of human monocyte CD163 upon activation of cell-surface Toll-like receptors.
J Leukoc Biol. 2007 Mar ;81(3):663-71. Epub 2006 Dec 12 .

PubMed
The effects of oral contraceptives on androgen levels and their relevance to pre...
The effects of oral contraceptives on androgen levels and their relevance to premenstrual mood and sexual interest: a comparison of two triphasic formulations containing norgestimate and either 35 or 25 microg of ethinyl estradiol.
Contraception. 2007 Jul ;76(1):8-17. Epub 2007 May 23 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...

You are here: NCBI > Literature > PubMed

Write to the Help Desk