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Pharmazie. 2006 Jul;61(7):652.

Absorption of myo-inositol hexakisphosphate (InsP6) through the skin in humans.

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  • 1Laboratory of Renal Lithiasis Research, Institute of Health Sciences Research, Faculty of Sciences, University of Balearic Islands, 07122 Palma de Mallorca, Spain. fgrases@uib.es


In this paper, we present a pilot study of the absorption of myo-inositol hexakisphosphate (InsP6) through the skin in humans. We found that, after topical treatment with a 4% InsP6 rich gel, InsP6 urinary excretion increased 54% compared to the control situation (participants submitted to an InsP6-poor diet for 15 days, n = 6), clearly demonstrating that InsP6 is absorbed through the skin of humans. These results demonstrate the topical application as a suitable administration route of InsP6 in humans.

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