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University of Vermont College of Medicine, Department of Anatomy & Neurobiology, 149 Beaumont Avenue, HSRF 416A, Burlington, VT 05405, USA. Beatrice.Girard@uvm.edu
Pituitary adenylate cyclase-activating polypeptide (PACAP) expression was quantified in explant-cultured guinea pig cardiac ganglia neurons. In explant culture, both the percentage of PACAP-immunoreactive neurons and pro-PACAP transcript levels increased significantly. Treatment with neurturin or glial-derived neurotrophic factor significantly suppressed the percentage of PACAP-IR neurons, but not pro-PACAP transcript levels.
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