Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Pediatr. 2006 Aug;149(2):220-6.

Environmental exposures and exhaled nitric oxide in children with asthma.

Author information

  • 1Cincinnati Children's Environmental Health Center, Division of General and Community Pediatrics, and the Division of Allergy and Clinical Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. adam.spanier@cchmc.org

Abstract

OBJECTIVE:

To evaluate the relation of environmental factors with exhaled nitric oxide (FENO) concentrations among asthmatic children.

STUDY DESIGN:

Cross-sectional analysis of 170 tobacco smoke-exposed children, ages 6 to 12 years, who have doctor-diagnosed asthma using measures of FENO, medication use, and exposures to settled indoor allergens and tobacco smoke.

RESULTS:

In multivariable analysis, child's age, uncarpeted flooring, not owning a cat, higher income, dust mite exposure, and being sensitized to any allergens were associated with higher FENO concentrations. Children who were sensitized to indoor allergens had an adjusted geometric mean FENO of 15.4 ppb (95% CI, 13.1, 18.2) compared with 10 ppb (95% CI, 8.2, 12.2) for unsensitized children. There was no statistically significant association of serum cotinine, hair cotinine, or reported corticosteroid therapy with FENO.

CONCLUSIONS:

FENO is higher among children who are sensitized to indoor allergens and exposed to dust mites. The results hold promise for the use of FENO as a tool to manage childhood asthma by using both pharmacologic and environmental treatments.

Comment in

PMID:
16887438
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk