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Malar J. 2006 Aug 4;5:69.

Absence of erythrocyte sequestration in a case of babesiosis in a splenectomized human patient.

Author information

  • 1School of Biochemistry and Molecular Biology Australian National University, Canberra, ACT 0200, Australia. ian.clark@anu.edu.au

Abstract

BACKGROUND:

The importance of vascular occlusion in the pathogenesis of human haemoprotozoal disease is unresolved.

METHODS:

Giemsa-stained tissue sections from a human case of Babesia microti infection in a splenectomized patient with chronic lymphocytic leukaemia and colon cancer were examined to ascertain the distribution of parasitized erythrocytes within the vascular lumen.

RESULTS:

No evidence of sequestration was observed.

CONCLUSION:

This first report on the vascular location of B. microti in human tissue suggests that severe multi-organ failure due to babesiosis is independent of sequestration of parasitized erythrocytes. A similar pathogenesis may also cause multi-organ failure in other intraerythrocytic protozoal infections, including falciparum malaria.

PMID:
16887045
[PubMed - indexed for MEDLINE]
PMCID:
PMC1552079
Free PMC Article
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