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    Clin Infect Dis. 2006 Sep 1;43(5):658-60. Epub 2006 Jul 26.

    Single-dose lopinavir-ritonavir acutely inhibits insulin-mediated glucose disposal in healthy volunteers.

    Source

    Department of Medicine, University of California, San Francisco, California, USA. galee@itsa.ucsf.edu

    Abstract

    Previously, we found that 4 weeks of treatment with lopinavir-ritonavir did not decrease insulin sensitivity but did increase adiponectin levels. In the present study, a single dose of lopinavir-ritonavir decreases insulin sensitivity but does not alter adiponectin levels. Insulin resistance from protease inhibitors may decrease with prolonged use; an increase in adiponectin levels may mediate this effect.

    PMID:
    16886163
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC3205942
    Free PMC Article

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