Cancer Res. 2006 Aug 1;66(15):7414-9.

Myopodin-mediated suppression of prostate cancer cell migration involves interaction with zyxin.

Source

Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. ypyu@pitt.edu

Abstract

Myopodin was identified as a tumor suppressor gene that is frequently deleted in aggressive prostate cancer. Expression of myopodin protein suppresses both tumor growth and metastasis in vitro and in vivo. In the present study employing a yeast two-hybrid system, we found that zyxin, a molecule known to regulate cell motility and migration, binds with myopodin with high affinity. The binding between zyxin and myopodin seems to be direct. Screening of a series of myopodin deletion mutants and peptide competition analyses revealed that myopodin is bound by zyxin at a site located within the sequence of the 19 amino acids at the myopodin COOH terminus. Importantly, this is the same region where the tumor suppressor activity of myopodin is located. The motility and invasion suppression activity of myopodin were significantly weakened in myopodin mutants lacking this sequence. Thus, our studies suggest that zyxin may be a critical functional regulator of myopodin.

PMID:: 16885336; [PubMed - indexed for MEDLINE]

Free full text

LinkOut - more resources

Full Text Sources

HighWire Press

Other Literature Sources

Medical

Prostate Cancer - MedlinePlus Health Information

Supplemental Content

Related citations

Phosphorylation and interaction of myopodin by integrin-link kinase lead to suppression of cell growth and motility in prostate cancer cells. [Oncogene. 2011]
Phosphorylation and interaction of myopodin by integrin-link kinase lead to suppression of cell growth and motility in prostate cancer cells.
Yu YP, Luo JH. Oncogene. 2011 Dec 8; 30(49):4855-63. Epub 2011 Jun 6.
Down-regulation of myopodin expression reduces invasion and motility of PC-3 prostate cancer cells. [Int J Oncol. 2009]
Down-regulation of myopodin expression reduces invasion and motility of PC-3 prostate cancer cells.
De Ganck A, De Corte V, Bruyneel E, Bracke M, Vandekerckhove J, Gettemans J. Int J Oncol. 2009 May; 34(5):1403-9.
Expression of myopodin induces suppression of tumor growth and metastasis. [Am J Pathol. 2004]
Expression of myopodin induces suppression of tumor growth and metastasis.
Jing L, Liu L, Yu YP, Dhir R, Acquafondada M, Landsittel D, Cieply K, Wells A, Luo JH. Am J Pathol. 2004 May; 164(5):1799-806.
Inactivation of myopodin expression associated with prostate cancer relapse. [Urology. 2006]
Inactivation of myopodin expression associated with prostate cancer relapse.
Yu YP, Tseng GC, Luo JH. Urology. 2006 Sep; 68(3):578-82. Epub 2006 Sep 18.
Review Cellular motility and prostatic carcinoma metastases. [Cancer Metastasis Rev. 1993]
Review Cellular motility and prostatic carcinoma metastases.
Mohler JL. Cancer Metastasis Rev. 1993 Mar; 12(1):53-67.

See reviews... See all...

Cited by 8 PubMed Central articles

MiR-886-3p regulates cell proliferation and migration, and is dysregulated in familial non-medullary thyroid cancer. [PLoS One. 2011]
MiR-886-3p regulates cell proliferation and migration, and is dysregulated in familial non-medullary thyroid cancer.
Xiong Y, Zhang L, Holloway AK, Wu X, Su L, Kebebew E. PLoS One. 2011; 6(10):e24717. Epub 2011 Oct 5.
Protein alterations associated with pancreatic cancer and chronic pancreatitis found in human plasma using global quantitative proteomics profiling. [J Proteome Res. 2011]
Protein alterations associated with pancreatic cancer and chronic pancreatitis found in human plasma using global quantitative proteomics profiling.
Pan S, Chen R, Crispin DA, May D, Stevens T, McIntosh MW, Bronner MP, Ziogas A, Anton-Culver H, Brentnall TA. J Proteome Res. 2011 May 6; 10(5):2359-76. Epub 2011 Mar 28.
Integrin alpha 7 interacts with high temperature requirement A2 (HtrA2) to induce prostate cancer cell death. [Am J Pathol. 2010]
Integrin alpha 7 interacts with high temperature requirement A2 (HtrA2) to induce prostate cancer cell death.
Zhu ZH, Yu YP, Zheng ZL, Song Y, Xiang GS, Nelson J, Michalopoulos G, Luo JH. Am J Pathol. 2010 Sep; 177(3):1176-86. Epub 2010 Jul 22.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Myopodin-mediated suppression of prostate cancer cell migration involves interac...
Myopodin-mediated suppression of prostate cancer cell migration involves interaction with zyxin.
Cancer Res. 2006 Aug 1 ;66(15):7414-9.

PubMed
Clinical syndrome associated with zolpidem ingestion in dogs: 33 cases (January ...
Clinical syndrome associated with zolpidem ingestion in dogs: 33 cases (January 1998-July 2000).
J Vet Intern Med. 2002 Mar-Apr ;16(2):208-10.

PubMed
Connoisseurs of care? Unannounced standardized patients' ratings of physicians.
Connoisseurs of care? Unannounced standardized patients' ratings of physicians.
Med Care. 2006 Dec ;44(12):1092-8.

PubMed
Biopsychosocial correlates of adjustment to pain among people with multiple scle...
Biopsychosocial correlates of adjustment to pain among people with multiple sclerosis.
Clin J Pain. 2008 Sep ;24(7):559-67.

PubMed
Intensity of exercise according to topography in professional cyclists.
Intensity of exercise according to topography in professional cyclists.
Med Sci Sports Exerc. 2003 Jul ;35(7):1209-15.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

Myopodin-mediated suppression of prostate cancer cell migration involves interaction with zyxin.

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Supplemental Content

Related citations

Cited by 8 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information