Send to

Choose Destination
See comment in PubMed Commons below
Cancer Res. 2006 Aug 1;66(15):7390-4.

MicroRNA-cancer connection: the beginning of a new tale.

Author information

  • 1Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University, 400 12th Avenue, Columbus, OH 43210, USA.


Cancer initiation and progression can involve microRNAs (miRNA), which are small noncoding RNAs that can regulate gene expression. Their expression profiles can be used for the classification, diagnosis, and prognosis of human malignancies. Loss or amplification of miRNA genes has been reported in a variety of cancers, and altered patterns of miRNA expression may affect cell cycle and survival programs. Germ-line and somatic mutations in miRNAs or polymorphisms in the mRNAs targeted by miRNAs may also contribute to cancer predisposition and progression. We propose that alterations in miRNA genes play a critical role in the pathophysiology of many, perhaps all, human cancers.

[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk