Vaccine. 2006 Nov 30;24(49-50):7037-45. Epub 2006 Jul 5.

Mumps vaccine virus strains and aseptic meningitis.

Bonnet MC, Dutta A, Weinberger C, Plotkin SA.

Source

Sanofi Pasteur, Medical Affairs International, 2, Avenue Pont Pasteur, 69007 Lyon, France. marie-claude.bonnet@sanofipasteur.com

Abstract

Mumps immunization can easily be included in national schedules, particularly if combined with measles or measles and rubella vaccines, but debate continues concerning the relative safety of various licensed mumps vaccine strains. The opportunities for control of mumps are also being affected by differences in the cost of the vaccines prepared with different strains of mumps virus. The present report evaluates available data on the association of the Urabe and other strains of mumps vaccine with the occurrence of aseptic meningitis. We also review the comparative immunogenicity and efficacies of the most widely used mumps vaccines in controlled clinical trials and field evaluations, and briefly examine relative cost as it relates to the implementation of national immunization programs. We conclude that extensive experience with the most widely used mumps vaccine strains in many countries has shown that the risk-benefit ratio of live mumps vaccines is highly favourable for vaccination, despite the occasional occurence of aseptic meningitis.

PMID:: 16884835; [PubMed - indexed for MEDLINE]

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Mumps Vaccine

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Outbreak of aseptic meningitis associated with mass vaccination with a urabe-containing measles-mumps-rubella vaccine: implications for immunization programs. [Am J Epidemiol. 2000]
Outbreak of aseptic meningitis associated with mass vaccination with a urabe-containing measles-mumps-rubella vaccine: implications for immunization programs.
Dourado I, Cunha S, Teixeira MG, Farrington CP, Melo A, Lucena R, Barreto ML. Am J Epidemiol. 2000 Mar 1; 151(5):524-30.
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Miller E, Goldacre M, Pugh S, Colville A, Farrington P, Flower A, Nash J, MacFarlane L, Tettmar R. Lancet. 1993 Apr 17; 341(8851):979-82.
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Review [Adverse effects following vaccinations and effectiveness of different live vaccines against mumps]. [Przegl Epidemiol. 2002]
Review [Adverse effects following vaccinations and effectiveness of different live vaccines against mumps].
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Review [Wide-spread inflammation of the parotid glands (mumps): an underestimated disease. II. Development, use, efficacy and safety of mumps vaccines]. [Przegl Epidemiol. 1998]
Review [Wide-spread inflammation of the parotid glands (mumps): an underestimated disease. II. Development, use, efficacy and safety of mumps vaccines].
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Cited by 3 PubMed Central articles

A 176 amino acid polypeptide derived from the mumps virus HN ectodomain shows immunological and biological properties similar to the HN protein. [Virol J. 2010]
A 176 amino acid polypeptide derived from the mumps virus HN ectodomain shows immunological and biological properties similar to the HN protein.
Herrera E, Barcenas P, Hernández R, Méndez A, Pérez-Ishiwara G, Barrón B. Virol J. 2010 Aug 20; 7:195. Epub 2010 Aug 20.
Relaxation of purifying selection on live attenuated vaccine strains of the family Paramyxoviridae. [Vaccine. 2009]
Relaxation of purifying selection on live attenuated vaccine strains of the family Paramyxoviridae.
Hughes AL. Vaccine. 2009 Mar 10; 27(11):1685-90. Epub 2009 Feb 3.
Characterization of large mumps outbreak among vaccinated Palestinian refugees. [J Clin Microbiol. 2009]
Characterization of large mumps outbreak among vaccinated Palestinian refugees.
Hindiyeh MY, Aboudy Y, Wohoush M, Shulman LM, Ram D, Levin T, Frank T, Riccardo F, Khalili M, Sawalha ES, et al. J Clin Microbiol. 2009 Mar; 47(3):560-5. Epub 2009 Jan 14.

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