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Genome Biol. 2006;7(8):R68. Epub 2006 Aug 2.

Primate-specific evolution of an LDLR enhancer.

Author information

  • 1Genomics Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA. QFWang@lbl.gov

Abstract

BACKGROUND:

Sequence changes in regulatory regions have often been invoked to explain phenotypic divergence among species, but molecular examples of this have been difficult to obtain.

RESULTS:

In this study we identified an anthropoid primate-specific sequence element that contributed to the regulatory evolution of the low-density lipoprotein receptor. Using a combination of close and distant species genomic sequence comparisons coupled with in vivo and in vitro studies, we found that a functional cholesterol-sensing sequence motif arose and was fixed within a pre-existing enhancer in the common ancestor of anthropoid primates.

CONCLUSION:

Our study demonstrates one molecular mechanism by which ancestral mammalian regulatory elements can evolve to perform new functions in the primate lineage leading to human.

PMID:
16884525
[PubMed - indexed for MEDLINE]
PMCID:
PMC1779597
Free PMC Article

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