Arch Neurol. 1975 Aug;32(8):535-8.

Phenytoin and membrane fluidity in myotonic dystrophy.

Roses AD, Butterfield A, Appel SH, Chestnut DB.

Abstract

Electron spin resonance spectroscopy was used to substantiate the presence of a membrane defect in myotonic erythrocytes. There was increased membrane fluidity and decreased polarity in myotonic membranes. Phenytoin (formerly diphenylhydantoin) "normalizes" fluidity differences in spectra derived from myotonic erythrocytes but has no significant effect on normal spectra. These experiments demonstrate the applicability of biophysical methods to human erythrocyte membranes and support the concept of a membrane defect in myotonic dystrophy that does not have a primary myopathic, neuropathic, or vascular cause.

PMID:: 168843; [PubMed - indexed for MEDLINE]

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Research Support, U.S. Gov't, P.H.S.

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Phenytoin

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PHENYTOIN SODIUM - HSDB

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Related citations in PubMed

Spin-label studies of erythrocytes in myotonic dystrophy: no increase in membrane fluidity. [Neurology. 1980]
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