Genes Dev. 2006 Aug 1;20(15):1993-7.

Small RNAs just got bigger: Piwi-interacting RNAs (piRNAs) in mammalian testes.

Source

School of Biological Sciences and Institute of Molecular Biology and Genetics, Seoul National University, Korea. narrykim@snu.ac.kr

Abstract

Small RNAs constitute a large family of regulatory molecules with diverse functions in eukaryotes. Hallmarks of small RNAs are their dependence on double-stranded RNAs (dsRNA)-specific RNase III-type enzymes for biogenesis and their association with Argonaute family proteins for the silencing process. At least two classes of small RNAs have previously been described: microRNAs (miRNAs) derived from hairpin-shaped precursors and small interfering RNAs (siRNAs) generated from long dsRNAs. Recent articles reported a novel class of small RNAs that are expressed specifically and abundantly in the spermatogenic cells of mice. These RNAs are bigger (26-31 nucleotides [nt]) than most previously described small RNAs (21-23 nt) and are associated with Piwi-subclade members of the Argonaute protein family. Although the biogenesis and function of these RNAs are yet to be determined, these findings may add new dimensions in small RNA biology and germline cell biology.

PMID:: 16882976; [PubMed - indexed for MEDLINE]

Free full text

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

A novel class of small RNAs in mouse spermatogenic cells. [Genes Dev. 2006]
A novel class of small RNAs in mouse spermatogenic cells.
Grivna ST, Beyret E, Wang Z, Lin H. Genes Dev. 2006 Jul 1; 20(13):1709-14. Epub 2006 Jun 9.
A novel class of small RNAs bind to MILI protein in mouse testes. [Nature. 2006]
A novel class of small RNAs bind to MILI protein in mouse testes.
Aravin A, Gaidatzis D, Pfeffer S, Lagos-Quintana M, Landgraf P, Iovino N, Morris P, Brownstein MJ, Kuramochi-Miyagawa S, Nakano T, et al. Nature. 2006 Jul 13; 442(7099):203-7. Epub 2006 Jun 4.
Review [A novel class of testis-specific small RNAs: piRNAs]. [Zhonghua Nan Ke Xue. 2008]
Review [A novel class of testis-specific small RNAs: piRNAs].
Ding XF, Li HG, Xiong CL. Zhonghua Nan Ke Xue. 2008 Feb; 14(2):163-5.
Review The Argonaute protein family. [Genome Biol. 2008]
Review The Argonaute protein family.
Höck J, Meister G. Genome Biol. 2008; 9(2):210. Epub 2008 Feb 26.
Review The biogenesis and function of PIWI proteins and piRNAs: progress and prospect. [Annu Rev Cell Dev Biol. 2009]
Review The biogenesis and function of PIWI proteins and piRNAs: progress and prospect.
Thomson T, Lin H. Annu Rev Cell Dev Biol. 2009; 25:355-76.

See reviews... See all...

Cited by 35 PubMed Central articles

Epigenetic memory in mammals. [Front Genet. 2011]
Epigenetic memory in mammals.
Migicovsky Z, Kovalchuk I. Front Genet. 2011; 2:28. Epub 2011 Jun 8.
Germline stem cell gene PIWIL2 mediates DNA repair through relaxation of chromatin. [PLoS One. 2011]
Germline stem cell gene PIWIL2 mediates DNA repair through relaxation of chromatin.
Yin DT, Wang Q, Chen L, Liu MY, Han C, Yan Q, Shen R, He G, Duan W, Li JJ, et al. PLoS One. 2011; 6(11):e27154. Epub 2011 Nov 16.
Transcriptome of small regulatory RNAs in the development of the zoonotic parasite Trichinella spiralis. [PLoS One. 2011]
Transcriptome of small regulatory RNAs in the development of the zoonotic parasite Trichinella spiralis.
Liu X, Song Y, Lu H, Tang B, Piao X, Hou N, Peng S, Jiang N, Yin J, Liu M, et al. PLoS One. 2011; 6(11):e26448. Epub 2011 Nov 1.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Small RNAs just got bigger: Piwi-interacting RNAs (piRNAs) in mammalian testes.
Small RNAs just got bigger: Piwi-interacting RNAs (piRNAs) in mammalian testes.
Genes Dev. 2006 Aug 1 ;20(15):1993-7.

PubMed
The contributions of anterior and posterior tibialis dysfunction to varus foot d...
The contributions of anterior and posterior tibialis dysfunction to varus foot deformity in patients with cerebral palsy.
J Bone Joint Surg Am. 2006 Aug ;88(8):1764-8.

PubMed
Comparison of respiratory physiologic features when infants are placed in car sa...
Comparison of respiratory physiologic features when infants are placed in car safety seats or car beds.
Pediatrics. 2006 Aug ;118(2):522-7.

PubMed
Factors influencing the composition of the intestinal microbiota in early infanc...
Factors influencing the composition of the intestinal microbiota in early infancy.
Pediatrics. 2006 Aug ;118(2):511-21.

PubMed
State newborn screening in the tandem mass spectrometry era: more tests, more fa...
State newborn screening in the tandem mass spectrometry era: more tests, more false-positive results.
Pediatrics. 2006 Aug ;118(2):448-56.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Small RNAs just got bigger: Piwi-interacting RNAs (piRNAs) in mammalian testes.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Cited by 35 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information