Eur J Neurosci. 2006 Jul;24(1):249-60.

Extinction is not a sufficient condition to prevent fear memories from undergoing reconsolidation in the basolateral amygdala.

Source

W.M. Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, NY, USA.

Abstract

Consolidated memories when reactivated may return to a state that requires protein synthesis in order to be restabilized (reconsolidation). It has been shown in a variety of systems that if reactivation induces significant extinction then extinction is the protein synthesis dependent memory state, rather than reconsolidation. Thus, extinction consolidation may prevent the memory from undergoing reconsolidation. We investigated whether such an interaction also exists between extinction and reconsolidation of fear memories within the amygdala, by using a within subjects experimental design. We found that inhibition of protein synthesis in the basolateral amygdala (BLA) impaired reconsolidation for both the briefly reactivated and extinguished fear memories suggesting that extinction is not a sufficient condition to prevent induction of reconsolidation in the amygdala. These findings demonstrate that extinction consolidation does not always interact with reconsolidation. Therefore, under these conditions, extinction is not a boundary condition on reconsolidation of fear memories in the basolateral amygdala.

PMID:: 16882021; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Research Support, Non-U.S. Gov't

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Medical

Memory - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Characterization of fear memory reconsolidation. [J Neurosci. 2004]
Characterization of fear memory reconsolidation.
Duvarci S, Nader K. J Neurosci. 2004 Oct 20; 24(42):9269-75.
Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval. [Nature. 2000]
Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval.
Nader K, Schafe GE, Le Doux JE. Nature. 2000 Aug 17; 406(6797):722-6.
Activation of extracellular signal-regulated kinase- mitogen-activated protein kinase cascade in the amygdala is required for memory reconsolidation of auditory fear conditioning. [Eur J Neurosci. 2005]
Activation of extracellular signal-regulated kinase- mitogen-activated protein kinase cascade in the amygdala is required for memory reconsolidation of auditory fear conditioning.
Duvarci S, Nader K, LeDoux JE. Eur J Neurosci. 2005 Jan; 21(1):283-9.
Review [Mechanisms of reconsolidation and extinction of fear memory]. [Nihon Shinkei Seishin Yakuriga...]
Review [Mechanisms of reconsolidation and extinction of fear memory].
Kida S, Fukushima H, Mamiya N. Nihon Shinkei Seishin Yakurigaku Zasshi. 2009 Jun; 29(3):125-33.
Review Erasing fear memories with extinction training. [J Neurosci. 2010]
Review Erasing fear memories with extinction training.
Quirk GJ, Paré D, Richardson R, Herry C, Monfils MH, Schiller D, Vicentic A. J Neurosci. 2010 Nov 10; 30(45):14993-7.

See reviews... See all...

Cited by 10 PubMed Central articles

Dietary Cholesterol Concentration and Duration Degrade Long-Term Memory of Classical Conditioning of the Rabbit's Nictitating Membrane Response. [Int J Alzheimers Dis. 2012]
Dietary Cholesterol Concentration and Duration Degrade Long-Term Memory of Classical Conditioning of the Rabbit's Nictitating Membrane Response.
Schreurs BG, Wang D, Smith-Bell CA, Burhans LB, Bell R, Gonzalez-Joekes J. Int J Alzheimers Dis. 2012; 2012:732634. Epub 2012 Apr 11.
Retrieval induces reconsolidation of fear extinction memory. [Proc Natl Acad Sci U S A. 2010]
Retrieval induces reconsolidation of fear extinction memory.
Rossato JI, Bevilaqua LR, Izquierdo I, Medina JH, Cammarota M. Proc Natl Acad Sci U S A. 2010 Dec 14; 107(50):21801-5. Epub 2010 Nov 30.
Review Behavioral and neural analysis of GABA in the acquisition, consolidation, reconsolidation, and extinction of fear memory. [Neuropsychopharmacology. 2010]
Review Behavioral and neural analysis of GABA in the acquisition, consolidation, reconsolidation, and extinction of fear memory.
Makkar SR, Zhang SQ, Cranney J. Neuropsychopharmacology. 2010 Jul; 35(8):1625-52. Epub 2010 Apr 21.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Extinction is not a sufficient condition to prevent fear memories from undergoin...
Extinction is not a sufficient condition to prevent fear memories from undergoing reconsolidation in the basolateral amygdala.
Eur J Neurosci. 2006 Jul ;24(1):249-60.

PubMed
Improving patient safety with team coordination: challenges and strategies of im...
Improving patient safety with team coordination: challenges and strategies of implementation.
J Obstet Gynecol Neonatal Nurs. 2006 Jul-Aug ;35(4):557-66.

PubMed
Water aerobics reduces sick leave due to low back pain during pregnancy.
Water aerobics reduces sick leave due to low back pain during pregnancy.
J Obstet Gynecol Neonatal Nurs. 2006 Jul-Aug ;35(4):465-71.

PubMed
Patients' expectancies, the alliance in pharmacotherapy, and treatment outcomes ...
Patients' expectancies, the alliance in pharmacotherapy, and treatment outcomes in bipolar disorder.
J Consult Clin Psychol. 2006 Aug ;74(4):671-6.

PubMed
Treatment-related changes in objectively measured parenting behaviors in the mul...
Treatment-related changes in objectively measured parenting behaviors in the multimodal treatment study of children with attention-deficit/hyperactivity disorder.
J Consult Clin Psychol. 2006 Aug ;74(4):649-57.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: