Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Annu Rev Entomol. 2007;52:171-92.

Gene regulation by chromatin structure: paradigms established in Drosophila melanogaster.

Author information

  • 1Department of Biology, Western Washington University, Bellingham, Washington 98225, USA. Sandra.Schulze@wwu.edu

Abstract

Studies in Drosophila melanogaster have revealed paradigms for regulating gene expression through chromatin structure, including mechanisms of gene activation and silencing. Regulation occurs at the level of individual genes, chromosomal domains, and entire chromosomes. The chromatin state is dynamic, allowing for changes in gene expression in response to cellular signals and/or environmental cues. Changes in chromatin result from the action of ATP-dependent chromatin-remodeling complexes, reversible epigenetic histone modifications, and the incorporation of histone variants. Many of the chromatin-based transcriptional regulatory mechanisms discovered in D. melanogaster are evolutionarily conserved and therefore serve as a foundation for studies in other organisms.

PMID:
16881818
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Atypon
    Loading ...
    Write to the Help Desk