Bipolar Disord. 2006 Aug;8(4):400-4.

Olanzapine in the prevention of postpartum psychosis and mood episodes in bipolar disorder.

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Department of Psychiatry and Obstetrics & Gynecology, University of Western Ontario, Ontario, Canada. vsharma@uwo.ca

Abstract

OBJECTIVES:

The use of olanzapine (OLZ) in the prevention of postpartum psychosis (PP) and mood episodes in women with bipolar disorder was investigated in a naturalistic, prospective study.

METHODS:

Eleven women received OLZ alone or in combination with an antidepressant or mood stabilizer, and 14 women received either antidepressants, mood stabilizers, or no medication for a minimum of 4 weeks after delivery.

RESULTS:

Two (18.2%) of the women in the OLZ group experienced a postpartum mood episode, whereas eight (57.1%) of the women in the No-OLZ group did.

CONCLUSIONS:

The role of OLZ in the prophylaxis of PP and mood episodes, particularly in women at high risk, clearly warrants further investigation.

PMID:: 16879140; [PubMed - indexed for MEDLINE]

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