Eksp Klin Farmakol. 2006 May-Jun;69(3):7-9.

[Participation of GABA--benzodiazepine receptor complex in the anxiolytic effect of piracetam].

[Article in Russian]

Moldavkin GM, Voronina TA, Neznamov GG, Maletova OK, Eliava NV.

Abstract

It is established that bicuculline, picrotoxin, and flumazenil (agents blocking different sites of GABA receptor) decrease the anxiolytic effect of piracetam as manifested in the conflict situation test. The most pronounced interaction was observed between piracetam and flumazenyl. On the background of antagonist action, piracetam inhibited the effects of flumazenil (but not those of bicuculline and picrotoxin). Based on these data, it is assumed that the anxiolytic effect of piracetam is mediated to some extent by benzodiazepine site of the GABA-benzodiazepine receptor complex.

PMID:: 16878489; [PubMed - indexed for MEDLINE]

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