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J Craniofac Surg. 2006 Jul;17(4):812-4.

Eosinophilic angiocentric fibrosis.

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  • 1Unit of Craniomaxillofacial Surgery, Center for Craniofacial Deformities and Orbital Surgery, S. Anna Hospital and University, Ferrara, Italy.


Eosinophilic angiocentric fibrosis (EAF) is a rare disease of the sinonasal tract, with histologic characteristic features like thick collagen bundles whirling around vessels in a fibrotic stroma with inflammatory cells rich in eosinophils. The Authors present a case of a 31-year-old man with bilateral nasal obstruction with no history of allergies or other systemic disease. The patient underwent a septoplasty with symptoms relieving. An EAF diagnosis was made. Differential diagnosis must rule out other lesions that may mimic EAF such as granuloma faciale, Kimura disease, Wegener granulomatosis, Churg-Strauss syndrome.

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