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Philos Trans R Soc Lond B Biol Sci. 2006 Jul 29;361(1471):1149-58.

Role of brain dopamine in food reward and reinforcement.

Author information

  • 1Intramural Research Program, Department of Health and Human Services, National Institute on Drug Abuse, Baltimore, MD 21224, USA. rwise@intra.nida.nih.gov

Abstract

The ability of food to establish and maintain response habits and conditioned preferences depends largely on the function of brain dopamine systems. While dopaminergic transmission in the nucleus accumbens appears sufficient for some forms of reward, the role of dopamine in food reward does not appear to be restricted to this region. Dopamine plays an important role in both the ability to energize feeding and to reinforce food-seeking behaviour; the role in energizing feeding is secondary to the prerequisite role in reinforcement. Dopaminergic activation is triggered by the auditory and visual as well as the tactile, olfactory, and gustatory stimuli of foods. While dopamine plays a central role in the feeding and food-seeking of normal animals, some food rewarded learning can be seen in genetically engineered dopamine-deficient mice.

PMID:
16874930
[PubMed - indexed for MEDLINE]
PMCID:
PMC1642703
Free PMC Article
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