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J Physiol. 2006 Oct 1;576(Pt 1):37-42. Epub 2006 Jul 27.

Prestin and the cochlear amplifier.

Author information

  • 1Department of Neurobiology & Physiology, Northwestern University, 2240 Campus Drive, Evanston, IL 60208, USA. p-dallos@northwestern.edu

Abstract

In non-mammalian, hair cell-bearing sense organs amplification is associated with mechano-electric transducer channels in the stereovilli (commonly called stereocilia). Because mammals possess differentiated outer hair cells (OHC), they also benefit from a novel electromotile process, powered by the motor protein, prestin. Here we consider new work pertaining to this protein and its potential role as the mammalian cochlear amplifier.

PMID:
16873410
[PubMed - indexed for MEDLINE]
PMCID:
PMC1995634
Free PMC Article

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