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Pediatr Clin North Am. 2006 Aug;53(4):751-65.

Application of genetic approaches to ocular disease.

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  • 1Medical College of Wisconsin, 925 North 87th Street, Milwaukee, WI 53226, USA. mruttum@mcw.edu

Abstract

The human eye is a complex organ whose development requires extraordinary coordination of developmental processes. Multiple genes responsible for the proper development and maintenance of the vertebrate eye have been identified and shown to be involved in a variety of debilitating ocular conditions. Genetic diseases involving the eye represent a leading cause of blindness in children and adults. This article summarizes current genetic approaches and their application to studies of ocular disease.

PMID:
16873003
[PubMed - indexed for MEDLINE]
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