J Nat Prod. 2006 Jul;69(7):1101-4.

A meroterpenoid NF-kappaB inhibitor and drimane sesquiterpenoids from Asafetida.

Appendino G, Maxia L, Bascope M, Houghton PJ, Sanchez-Duffhues G, Muñoz E, Sterner O.

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Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche, Università del Piemonte Orientale, Via Bovio 6, 28100 Novara, Italy. appendino@pharm.unipmn.it

Abstract

Investigation of an acetone extract from Asafetida afforded two drimane sesquiterpene dienones (fetidones A and B, 1a,b) and several known sesquiterpene coumarin ethers, one of which (8-acetoxy-5-hydroxyumbelliprenin, 2a) showed potent and specific NF-kappaB-inhibiting properties. This, coupled to a negligible cytotoxicity, qualifies 2a as a new anti-inflammatory chemotype, and its occurrence in asafetida might rationalize the use of this gum resin to alleviate and prevent colon inflammatory disturbances.

PMID:: 16872156; [PubMed - indexed for MEDLINE]

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A meroterpenoid NF-kappaB inhibitor and drimane sesquiterpenoids from Asafetida.
A meroterpenoid NF-kappaB inhibitor and drimane sesquiterpenoids from Asafetida.
J Nat Prod. 2006 Jul ;69(7):1101-4.

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