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    J Pharm Pharmacol. 1991 Nov;43(11):805-6.

    Protein binding of cefpiramide in the plasma of various species.

    Ohshima T, Hasegawa T, Johno I, Kitazawa S.

    Source

    Department of Hospital Pharmacy, School of Medicine, Nagoya University, Japan.

    Abstract

    The plasma protein binding of cefpiramide in man, dog, rabbit and rat was examined. Cefpiramide was more strongly bound to human plasma than to animal plasma and was exclusively bound to albumin. The characteristics of the protein binding of cefpiramide is one of the factors influencing the extrapolation of drug disposition from animals to man.

    PMID:
    1686912
    [PubMed - indexed for MEDLINE]

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