AIDS. 2006 Aug 1;20(12):1675-7.

Ezetimibe effectively decreases LDL-cholesterol in HIV-infected patients.

Coll B, Aragonés G, Parra S, Alonso-Villaverde C, Masana L.

Source

Centre de Recerca Biomédica, Reus, Spain.

Abstract

We tested the security and efficacy of ezetimibe in the treatment of HIV-associated dyslipemia. Twenty HIV-infected patients were randomly assigned to receive ezetimibe 10 mg/day or fluvastatin 80 mg/day. Patients receiving ezetimibe experienced a statistically significant (P = 0.003) 20% reduction in the concentration of LDL-cholesterol, similar to that observed with fluvastatin (24%, P between groups 0.70). We concluded that ezetimibe monotherapy effectively decreases LDL-cholesterol in HIV-infected patients.

PMID:: 16868453; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Medical

Molecular Biology Databases

Supplemental Content

Related citations

Effects of fluvastatin extended-release (80 mg) alone and in combination with ezetimibe (10 mg) on low-density lipoprotein cholesterol and inflammatory parameters in patients with primary hypercholesterolemia: a 12-week, multicenter, randomized, open-label, parallel-group study. [Clin Ther. 2008]
Effects of fluvastatin extended-release (80 mg) alone and in combination with ezetimibe (10 mg) on low-density lipoprotein cholesterol and inflammatory parameters in patients with primary hypercholesterolemia: a 12-week, multicenter, randomized, open-label, parallel-group study.
Alvarez-Sala LA, Cachofeiro V, Masana L, Suarez C, Pinilla B, Plana N, Trias F, Moreno MA, Gambus G, Lahera V, et al. Clin Ther. 2008 Jan; 30(1):84-97.
The effect of fluvastatin on the pharmacokinetics and pharmacodynamics of ezetimibe. [Curr Med Res Opin. 2005]
The effect of fluvastatin on the pharmacokinetics and pharmacodynamics of ezetimibe.
Reyderman L, Kosoglou T, Cutler DL, Maxwell S, Statkevich P. Curr Med Res Opin. 2005 Aug; 21(8):1171-9.
Differential effects of fluvastatin alone or in combination with ezetimibe on lipoprotein subfractions in patients at high risk of coronary events. [Eur J Clin Invest. 2010]
Differential effects of fluvastatin alone or in combination with ezetimibe on lipoprotein subfractions in patients at high risk of coronary events.
Stojakovic T, de Campo A, Scharnagl H, Sourij H, Schmölzer I, Wascher TC, März W. Eur J Clin Invest. 2010 Mar; 40(3):187-94. Epub 2010 Jan 7.
Review Ezetimibe monotherapy for cholesterol lowering in 2,722 people: systematic review and meta-analysis of randomized controlled trials. [J Intern Med. 2009]
Review Ezetimibe monotherapy for cholesterol lowering in 2,722 people: systematic review and meta-analysis of randomized controlled trials.
Pandor A, Ara RM, Tumur I, Wilkinson AJ, Paisley S, Duenas A, Durrington PN, Chilcott J. J Intern Med. 2009 May; 265(5):568-80. Epub 2008 Dec 28.
Review The effects of ezetimibe on LDL-cholesterol: quantitative or qualitative changes? [Atherosclerosis. 2009]
Review The effects of ezetimibe on LDL-cholesterol: quantitative or qualitative changes?
Rizzo M, Rini GB, Spinas GA, Berneis K. Atherosclerosis. 2009 Jun; 204(2):330-3. Epub 2008 Oct 14.

See reviews... See all...

Cited by 8 PubMed Central articles

Hypertriglyceridemia, Metabolic Syndrome, and Cardiovascular Disease in HIV-Infected Patients: Effects of Antiretroviral Therapy and Adipose Tissue Distribution. [Int J Vasc Med. 2012]
Hypertriglyceridemia, Metabolic Syndrome, and Cardiovascular Disease in HIV-Infected Patients: Effects of Antiretroviral Therapy and Adipose Tissue Distribution.
van Wijk JP, Cabezas MC. Int J Vasc Med. 2012; 2012:201027. Epub 2011 Aug 22.
Review Dyslipidemia and lipid management in HIV-infected patients. [Curr Opin Endocrinol Diabetes Obes. 2011]
Review Dyslipidemia and lipid management in HIV-infected patients.
Lo J. Curr Opin Endocrinol Diabetes Obes. 2011 Apr; 18(2):144-7.
Review Dyslipidemia and its Treatment in HIV Infection. [Top HIV Med. 2010]
Review Dyslipidemia and its Treatment in HIV Infection.
Grunfeld C. Top HIV Med. 2010 Aug-Sep; 18(3):112-8.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Ezetimibe effectively decreases LDL-cholesterol in HIV-infected patients.
Ezetimibe effectively decreases LDL-cholesterol in HIV-infected patients.
AIDS. 2006 Aug 1 ;20(12):1675-7.

PubMed
Update on chemotherapy for advanced bladder cancer.
Update on chemotherapy for advanced bladder cancer.
J Urol. 2005 Jul ;174(1):14-20.

PubMed
Prevalence of toxic shock syndrome toxin 1-producing Staphylococcus aureus and t...
Prevalence of toxic shock syndrome toxin 1-producing Staphylococcus aureus and the presence of antibodies to this superantigen in menstruating women.
J Clin Microbiol. 2005 Sep ;43(9):4628-34.

PubMed
A novel type of SYT/SSX fusion: methodological and biological implications.
A novel type of SYT/SSX fusion: methodological and biological implications.
Mod Pathol. 2002 Jun ;15(6):679-85.

PubMed
The dengue vector Aedes aegypti: what comes next.
The dengue vector Aedes aegypti: what comes next.
Microbes Infect. 2010 Apr ;12(4):272-9. Epub 2010 Jan 22 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

Ezetimibe effectively decreases LDL-cholesterol in HIV-infected patients.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Molecular Biology Databases

Supplemental Content

Related citations

Cited by 8 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information