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Physiology (Bethesda). 2006 Aug;21:259-68.

Protein-mediated fatty acid uptake: novel insights from in vivo models.

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  • 1Palo Alto Medical Foundation Research Institute, Palo Alto, CA, USA.


Long-chain fatty acids are both important metabolites as well as signaling molecules. Fatty acid transport proteins are key mediators of cellular fatty acid uptake and recent transgenic and knockout animal models have provided new insights into their contribution to energy homeostasis and to pathological processes, including obesity and insulin desensitization.

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