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Cytojournal. 2006 Jul 25;3:17.

Lack of BRAF mutations in hyalinizing trabecular neoplasm.

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  • 1Department of Pathology, 3400 Spruce Street, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA. baloch@mail.med.upenn.edu

Abstract

The hyalinizing trabecular neoplasm (HTN) of the thyroid is an unusual and controversial lesion. Some consider it a peculiar type of papillary thyroid carcinoma (PTC) because of its nuclear features and presence of psammoma bodies. Others consider it an adenoma. Molecular studies have found RET/PTC translocations in some examples, supporting HTN as a PTC; however mutations in BRAF (another marker for PTC) have not been found. We report two cases of classic HTN and a case of trabecular PTC and show BRAF mutations in the latter and not in HTN. Trabecular growth pattern is insufficient for a diagnosis of HTN and lesions with such a pattern and nuclear features of PTC are cancers. Morphologically classic HTN are not associated with metastatic potential and should be considered adenomas.

PMID:
16867191
[PubMed]
PMCID:
PMC1544348
Free PMC Article
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