J Am Chem Soc. 2006 Aug 2;128(30):9963-70.

Structure of the human telomere in K+ solution: an intramolecular (3 + 1) G-quadruplex scaffold.

Luu KN, Phan AT, Kuryavyi V, Lacroix L, Patel DJ.

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Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

Abstract

We present the intramolecular G-quadruplex structure of human telomeric DNA in physiologically relevant K(+) solution. This G-quadruplex, whose (3 + 1) topology differs from folds reported previously in Na(+) solution and in a K(+)-containing crystal, involves the following: one anti.syn.syn.syn and two syn.anti.anti.anti G-tetrads; one double-chain reversal and two edgewise loops; three G-tracts oriented in one direction and the fourth in the opposite direction. The topological characteristics of this (3 + 1) G-quadruplex scaffold should provide a unique platform for structure-based anticancer drug design targeted to human telomeric DNA.

PMID:: 16866556; [PubMed - indexed for MEDLINE]

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PDB/2GKU

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Cited by 63 PubMed Central articles

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G-quadruplex structure and stability illuminated by 2-aminopurine phasor plots. [Nucleic Acids Res. 2012]
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Buscaglia R, Jameson DM, Chaires JB. Nucleic Acids Res. 2012 May 1; 40(9):4203-15. Epub 2012 Jan 12.
A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands. [Nat Chem. 2011]
A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands.
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Structures reported by this article

Monomeric Human Telomere Dna Tetraplex With 3+1 Strand Fold Topology, Two Edgewise Loops And Double-Chain Reversal Loop, Nmr, 12 Structures

PDB: 2GKU

Source: Homo sapiens

Method: Solution Nmr

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