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Neurology. 2006 Jul 25;67(2):340-2.

Sodium valproate vs phenytoin in status epilepticus: a pilot study.

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  • 1Department of Neurology, Sanjay Gandhi PGIMS, Lucknow, India. drukmisra@rediffmail.com


Sixty-eight patients with convulsive status epilepticus (SE) were randomly assigned to two groups to study the efficacy of sodium valproate (VPA) and phenytoin (PHT). Seizures were aborted in 66% in the VPA group and 42% in the PHT group. As a second choice in refractory patients, VPA was effective in 79% and PHT was effective in 25%. The side effects in the two groups did not differ. Sodium valproate may be preferred in convulsive SE because of its higher efficacy.

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