Regulation of PTEN function as a PIP3 gatekeeper through membrane interaction

Cell Cycle. 2006 Jul;5(14):1523-7. doi: 10.4161/cc.5.14.3005. Epub 2006 Jul 17.

Abstract

PTEN, one of the most frequently mutated genes in human cancer, acts as a tumor suppressor by dephosphorylating the plasma membrane lipid second messenger phosphoinositide-3,4,5-trisphosphate (PIP3) generated by the action of PI3Kinases. PTEN activity to prevent elevated levels of PIP3 and tumorigenesis depends on its interaction with the lipid bilayer. PTEN binds dynamically to the plasma membrane through a complex mix of protein-lipid and protein-protein interactions and the translocation is regulated by several mechanisms including C-terminal tail phosphorylations. Here we have summarized our current view of the interaction of PTEN with the plasma membrane and what the implications are for cancer biology.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Cell Membrane / metabolism*
  • Humans
  • Neoplasms / etiology
  • PTEN Phosphohydrolase / metabolism*
  • PTEN Phosphohydrolase / physiology
  • Phosphatidylinositols / metabolism*
  • Phosphorylation
  • Protein Binding
  • Protein Transport
  • Tumor Suppressor Proteins

Substances

  • Phosphatidylinositols
  • Tumor Suppressor Proteins
  • phosphoinositide-3,4,5-triphosphate
  • PTEN Phosphohydrolase
  • PTEN protein, human