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Cancer Biol Ther. 2006 Jul;5(7):756-9. Epub 2006 Jul 1.

Targeting XBP-1 as a novel anti-cancer strategy.

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  • 1Stanford University, Department of Radiation Oncology, CA 94305-5152, USA.


The survival and growth of tumor cells within the microenvironment of a solid tumor necessitates the adaptation of these cells to ER stress. Hypoxia, in the context of the tumor microenvironment, is a critical ER stress that activates the unfolded protein response (UPR). This review focuses on the role of the IRE1-XBP1 branch of the UPR and its role in mediating cell survival and tumor growth. Inhibition of this pathway will be discussed as a therapeutic strategy.

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