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    Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2006 Jun;31(3):340-4, 349.

    [Sorcin overexpression and multidrug resistance in human gastric cancer cells]

    [Article in Chinese]

    Yi H, Yang YX, Tang CE, Chen ZC, Zhang GY, Xiao ZQ.

    Key Laboratory of Cancer Proteomics of Ministry of Health of China, Xiangya Hospital, Central South University, Changsha.

    OBJECTIVE: To screen multidrug resistance (MDR) related proteins in human gastric cancer using proteomics technique. METHODS: Two-dimensional electrophoresis (2-DE) was used to separate the total proteins of vincristine-resistant human gastric cancer cell line SGC7901/VCR and its counterpart SGC7901. PDQuest software was used to analyze 2-DE images, and the differential expression proteins between the 2 cell lines were identified by both MALDI-TOF-MS and ESI-Q-TOF. The differential expression level of sorcin, one of the identified proteins, was confirmed by western blot analysis. The effect of sorcin on the development of MDR of SGC7901/VCR was determined by antisense oligonucleotides (ASO) technique. RESULTS: Sorcin as a high expression protein in SGC7901/VCR was identified and the suppression of sorcin expression by sorcin ASO could enhance the vincristine chemosensitivity in SGC7901/VCR. CONCLUSION: Sorcin overexpression is related to MDR in human gastric cancer cell line SGC7901/VCR.

    PMID: 16859119 [PubMed - indexed for MEDLINE]

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    Patient drug information

    • Vincristine (Oncovin®, Vincasar®)

      Your doctor has ordered the drug vincristine to help treat your illness. The drug is given by injection into a vein.

    • Source: AHFS Consumer Medication Information

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