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Scand J Infect Dis. 2006;38(8):733-5.

Genotyping of CYP2B6 and therapeutic drug monitoring in an HIV-infected patient with high efavirenz plasma concentrations and severe CNS side-effects.

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  • 1Department of Infectious Diseases, Rigshospitalet, Copenhagen University Hospital, Copenhagen. sofiemath@stud.ku.dk

Abstract

We present a case with important pharmacogenetic and pharmacokinetic aspects of antiretroviral therapy in a patient with high efavirenz concentrations, severe CNS side-effects and low lopinavir concentrations. Despite therapeutic drug monitoring and subsequent efavirenz dosage reductions, side-effects did not resolve completely and lopinavir concentrations remained relatively low.

PMID:
16857630
[PubMed - indexed for MEDLINE]
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