J Pharm Pharmacol. 1991 Sep;43(9):667-9.

Antihaemostatic and antithrombotic effect of some antiplatelet agents isolated from Chinese herbs.

Teng CM, Ko FN, Wang JP, Lin CN, Wu TS, Chen CC, Huang TF.

Source

Pharmacological Institute, College of Medicine, National Taiwan University, Taipei.

Abstract

Five antiplatelet agents have been isolated from Chinese herbs. Apigenin and magnolol are inhibitors of thromboxane synthesis, while osthole, protopine and norathyriol are inhibitiors of phosphoinositide breakdown. Thirty min after intraperitoneal (i.p.) administration of these drugs, tail bleeding time of mice was prolonged markedly in a dose-dependent manner by norathyriol, protopine, osthole and magnolol, but not by apigenin. However, the antiplatelet agents (up to 200 mg kg-1, i.p.) could not prevent acute thromboembolic death in mice. In endotoxin-induced experimental disseminated intravascular coagulation in rats, norathyriol (50-100 mg kg-1, i.p.) prevented the decrease in platelet counts and fibrinogen, and the prolongation of plasma prothrombin time. Norathyriol (100 mg kg-1, i.p.) also suppressed ex-vivo platelet aggregation induced by collagen and ADP in rat plasma.

PMID:: 1685529; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Research Support, Non-U.S. Gov't

MeSH Terms

Substances

LinkOut - more resources

Other Literature Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Synthesis and antiplatelet effects of the new antithrombotic agent aspalatone with low ulcerogenicity. [Arzneimittelforschung. 1994]
Synthesis and antiplatelet effects of the new antithrombotic agent aspalatone with low ulcerogenicity.
Han BH, Suh DY, Yang HO, Park YH, Kang YH, Kim YC. Arzneimittelforschung. 1994 Oct; 44(10):1122-6.
Antiplatelet and antithrombotic activities of NQ301, 2-chloro-3-(4-acetophenyl)-amino-1,4-naphthoquinone. [Biol Pharm Bull. 1999]
Antiplatelet and antithrombotic activities of NQ301, 2-chloro-3-(4-acetophenyl)-amino-1,4-naphthoquinone.
Kang WS, Ryu CK, Chung KH, Ko MW, Joo JC, Yuk DY, Yoo HS, Yun YP. Biol Pharm Bull. 1999 Dec; 22(12):1284-7.
Antithrombotic and antiplatelet activities of 2-chloro-3-[4-(ethylcarboxy)-phenyl]-amino-1,4-naphthoquinone (NQ12), a newly synthesized 1,4-naphthoquinone derivative. [Biochem Pharmacol. 2000]
Antithrombotic and antiplatelet activities of 2-chloro-3-[4-(ethylcarboxy)-phenyl]-amino-1,4-naphthoquinone (NQ12), a newly synthesized 1,4-naphthoquinone derivative.
Yuk DY, Ryu CK, Hong JT, Chung KH, Kang WS, Kim Y, Yoo HS, Lee MK, Lee CK, Yun YP. Biochem Pharmacol. 2000 Oct 1; 60(7):1001-8.
Review 8th Seah Cheng Siang Memorial Lecture: new antithrombotic agents. [Ann Acad Med Singapore. 1999]
Review 8th Seah Cheng Siang Memorial Lecture: new antithrombotic agents.
Verstraete M. Ann Acad Med Singapore. 1999 May; 28(3):347-62.
Review Novel antithrombotic drugs in development. [Drugs. 1995]
Review Novel antithrombotic drugs in development.
Verstraete M, Zoldhelyi P. Drugs. 1995 Jun; 49(6):856-84.

See reviews... See all...

Cited by 5 PubMed Central articles

Anti-arthritic effects of magnolol in human interleukin 1β-stimulated fibroblast-like synoviocytes and in a rat arthritis model. [PLoS One. 2012]
Anti-arthritic effects of magnolol in human interleukin 1β-stimulated fibroblast-like synoviocytes and in a rat arthritis model.
Wang JH, Shih KS, Liou JP, Wu YW, Chang AS, Wang KL, Tsai CL, Yang CR. PLoS One. 2012; 7(2):e31368. Epub 2012 Feb 16.
Fibrinolytic effects of Ginkgo biloba extract. [Exp Clin Cardiol. 2005]
Fibrinolytic effects of Ginkgo biloba extract.
Naderi GA, Asgary S, Jafarian A, Askari N, Behagh A, Aghdam RH. Exp Clin Cardiol. 2005 Summer; 10(2):85-7.
Effector mechanism of magnolol-induced apoptosis in human lung squamous carcinoma CH27 cells. [Br J Pharmacol. 2003]
Effector mechanism of magnolol-induced apoptosis in human lung squamous carcinoma CH27 cells.
Yang SE, Hsieh MT, Tsai TH, Hsu SL. Br J Pharmacol. 2003 Jan; 138(1):193-201.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Antihaemostatic and antithrombotic effect of some antiplatelet agents isolated f...
Antihaemostatic and antithrombotic effect of some antiplatelet agents isolated from Chinese herbs.
J Pharm Pharmacol. 1991 Sep ;43(9):667-9.

PubMed
Diastolic heart failure--a common and lethal condition by any name.
Diastolic heart failure--a common and lethal condition by any name.
N Engl J Med. 2006 Jul 20 ;355(3):308-10.

PubMed
Causes of chronic diarrhea.
Causes of chronic diarrhea.
N Engl J Med. 2006 Jul 20 ;355(3):236-9.

PubMed
GAMT deficiency: features, treatment, and outcome in an inborn error of creatine...
GAMT deficiency: features, treatment, and outcome in an inborn error of creatine synthesis.
Neurology. 2006 Aug 8 ;67(3):480-4. Epub 2006 Jul 19 .

PubMed
The physiology of human glucocorticoid receptor beta (hGRbeta) and glucocorticoi...
The physiology of human glucocorticoid receptor beta (hGRbeta) and glucocorticoid resistance.
Ann N Y Acad Sci. 2006 Jun ;1069:1-9.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: