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    J Bacteriol. 2006 Aug;188(15):5640-5.

    Transcriptional profile of Haemophilus influenzae: effects of iron and heme.

    Whitby PW, Vanwagoner TM, Seale TW, Morton DJ, Stull TL.

    Department of Pediatrics, CHO 2308, 940 NE 13th St., Oklahoma City, OK 73104, USA.

    Haemophilus influenzae requires either heme or a porphyrin and iron source for growth. Microarray studies of H. influenzae strain Rd KW20 identified 162 iron/heme-regulated genes, representing approximately 10% of the genome, with > or =1.5-fold changes in transcription in response to iron/heme availability in vitro. Eighty genes were preferentially expressed under iron/heme restriction; 82 genes were preferentially expressed under iron/heme-replete conditions.

    PMID: 16855256 [PubMed - indexed for MEDLINE]

    PMCID: PMC1540045

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