Abstract
Agonists of peroxisome proliferator-activated receptor gamma (PPAR gamma) are of interest as a treatment for diabetes, which prompted the identification of a new class of non-TZD PPAR gamma agonist. Moreover, compound 14c has displayed the most active agonistic activity with an EC50 value of 50 nM, in addition to exhibiting a new binding mode in the X-ray cocrystal structure.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Crystallography, X-Ray
-
Humans
-
Indenes / chemical synthesis*
-
Indenes / chemistry
-
Indenes / pharmacology
-
Ligands
-
Mice
-
Models, Molecular
-
Molecular Structure
-
NIH 3T3 Cells
-
PPAR gamma / agonists*
-
PPAR gamma / chemistry*
Substances
-
1-oxo-3-phenyl-6-(3-phenylpropoxy)-1H-indene-2-carboxylic acid ethyl ester
-
Indenes
-
Ligands
-
PPAR gamma