Fe(III)-templated Gd(III) self-assemblies-a new route toward macromolecular MRI contrast agents

J Am Chem Soc. 2006 Jul 26;128(29):9272-3. doi: 10.1021/ja061323j.

Abstract

The self-assembly of supramolcular clusters of Gd(III) hydroxypyridinone complexes, templated by an Fe(III) terephthalamide center, is presented. The peripheral Gd(III) ions are each coordinated by two water molecules which exchange rapidly with the bulk solvent. These properties, along with the high rigidity of the supramolecules, efficiently increase the rotational correlation times of the cluster, resulting in high relaxivities at high magnetic fields and hence making these complexes good candidates for MRI contrast agents.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Contrast Media / chemistry*
  • Gadolinium / chemistry*
  • Iron / chemistry*
  • Magnetic Resonance Imaging / methods*
  • Molecular Structure

Substances

  • Contrast Media
  • Gadolinium
  • Iron