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Genes Dev. 2006 Jul 15;20(14):1880-4.

Geminin is essential to prevent endoreduplication and to form pluripotent cells during mammalian development.

Author information

  • 1Medical Research Council Cancer Cell Unit, Hutchison/MRC Research Centre, UK. mg322@hutchison-mrc.cam.ac.uk

Abstract

In multicellular eukaryotes, geminin prevents overreplication of DNA in proliferating cells. Here, we show that genetic ablation of geminin in the mouse prevents formation of inner cell mass (ICM) and causes premature endoreduplication at eight cells, rather than 32 cells. All cells in geminin-deficient embryos commit to the trophoblast cell lineage and consist of trophoblast giant cells (TGCs) only. Geminin is also down-regulated in TGCs of wild-type blastocysts during S and gap-like phases by proteasome-mediated degradation, suggesting that loss of geminin is part of the mechanism regulating endoreduplication.

PMID:
16847348
[PubMed - indexed for MEDLINE]
PMCID:
PMC1522086
Free PMC Article
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