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Neuron. 2006 Jul 20;51(2):239-49.

Serotonin reciprocally regulates melanocortin neurons to modulate food intake.

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  • 1Department of Clinical Biochemistry, Addenbrooke's Hospital, University of Cambridge, Cambridge, CB2 2QQ, United Kingdom. lkh30@medschl.cam.ac.uk

Abstract

The neural pathways through which central serotonergic systems regulate food intake and body weight remain to be fully elucidated. We report that serotonin, via action at serotonin1B receptors (5-HT1BRs), modulates the endogenous release of both agonists and antagonists of the melanocortin receptors, which are a core component of the central circuitry controlling body weight homeostasis. We also show that serotonin-induced hypophagia requires downstream activation of melanocortin 4, but not melanocortin 3, receptors. These results identify a primary mechanism underlying the serotonergic regulation of energy balance and provide an example of a centrally derived signal that reciprocally regulates melanocortin receptor agonists and antagonists in a similar manner to peripheral adiposity signals.

PMID:
16846858
[PubMed - indexed for MEDLINE]
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