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Am J Physiol Gastrointest Liver Physiol. 2007 Jan;292(1):G165-72. Epub 2006 Jul 13.

Mice with experimental colitis show an altered metabolism with decreased metabolic rate.

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  • 1Department of Integrative Pharmacology, Gastrointestinal Biology, AstraZeneca Research and Development, Mölndal, Sweden. silvia.melgar@astrazeneca.com

Abstract

Patients with inflammatory bowel disease (IBD) suffer from body weight loss, malnutrition, and several other metabolic alterations affecting their quality of life. The aim of this study was to investigate the metabolic changes that may occur during acute and chronic colonic inflammation induced by dextran sulfate sodium (DSS) in mice. Clinical symptoms and inflammatory markers revealed the presence of an ongoing inflammatory response in the DSS-treated mice. Mice with acute inflammation had decreased body weight, respiratory exchange ratios (RER), food intake, and body fat content. Mice with chronic inflammation had decreased nutrient uptake, body fat content, locomotor activity, metabolic rates, and bone mineral density. Despite this, the body weight, food and water intake, lean mass, and RER of these mice returned to values similar to those in healthy controls. Thus, murine experimental colitis is associated with significant metabolic alterations similar to IBD patients. Our data show that the metabolic responses during acute and chronic inflammation are different, although the metabolic rate is reduced in both phases. These observations suggest compensatory metabolic alterations in chronic colitis resulting in a healthy appearance despite gross colon pathology.

PMID:
16844678
[PubMed - indexed for MEDLINE]
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