Neuroreport. 1991 Sep;2(9):525-8.

Effects of mianserin and fluoxetine on axonal regeneration of brain catecholamine neurons.

Source

Department of Physiology, Faculty of Medicine, Kanazawa University, Japan.

Abstract

The antidepressants, mianserin (MIA) and fluoxetine (FLU), were examined to see if they could induce regeneration of catecholaminergic axons in the rat cerebral cortex. MIA, which has a small or no effect in noradrenaline (NA) reuptake but may enhance release by blocking presynaptic inhibition mediated by alpha 2-adrenoceptors, induced regeneration of catecholamine fibers. In contrast, FLU, a potent reuptake blocker of serotonin was ineffective. This finding suggests that the antidepressant-induced regeneration of cortical catecholamine fibers is associated, at least in part, with enhanced noradrenergic transmission.

PMID:: 1684303; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Ovid Technologies, Inc.

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Review Axonal sprouting of noradrenergic locus coeruleus neurons following repeated stress and antidepressant treatment. [Prog Brain Res. 1991]
Review Axonal sprouting of noradrenergic locus coeruleus neurons following repeated stress and antidepressant treatment.
Nakamura S. Prog Brain Res. 1991; 88:587-98.
In the rat forced swimming test, NA-system mediated interactions may prevent the 5-HT properties of some subacute antidepressant treatments being expressed. [Eur Neuropsychopharmacol. 2002]
In the rat forced swimming test, NA-system mediated interactions may prevent the 5-HT properties of some subacute antidepressant treatments being expressed.
Rénéric JP, Bouvard M, Stinus L. Eur Neuropsychopharmacol. 2002 Apr; 12(2):159-71.
Differential blockade by (-)mianserin of the alpha 2-adrenoceptors mediating inhibition of noradrenaline and serotonin release from rat brain synaptosomes. [Naunyn Schmiedebergs Arch Phar...]
Differential blockade by (-)mianserin of the alpha 2-adrenoceptors mediating inhibition of noradrenaline and serotonin release from rat brain synaptosomes.
Raiteri M, Maura G, Gemignani A, Pittaluga A. Naunyn Schmiedebergs Arch Pharmacol. 1983 Mar; 322(2):180-2.
Review Pharmacology of antidepressants: selectivity or multiplicity? [J Clin Psychiatry. 1999]
Review Pharmacology of antidepressants: selectivity or multiplicity?
Westenberg HG. J Clin Psychiatry. 1999; 60 Suppl 17:4-8; discussion 46-8.
Presynaptic alpha-block and inhibition of noradrenaline and 5-hydroxytryptamine reuptake by a series of compounds related to mianserin. [J Pharm Pharmacol. 1981]
Presynaptic alpha-block and inhibition of noradrenaline and 5-hydroxytryptamine reuptake by a series of compounds related to mianserin.
Nickolson VJ, Wieringa JH. J Pharm Pharmacol. 1981 Dec; 33(12):760-6.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.

Recent activity

Clear Turn Off Turn On

Effects of mianserin and fluoxetine on axonal regeneration of brain catecholamin...
Effects of mianserin and fluoxetine on axonal regeneration of brain catecholamine neurons.
Neuroreport. 1991 Sep ;2(9):525-8.

PubMed
Association between infant birth weight and maternal cardiovascular risk factors...
Association between infant birth weight and maternal cardiovascular risk factors in the health, aging, and body composition study.
Ann Epidemiol. 2007 Jan ;17(1):36-43. Epub 2006 Jul 12 .

PubMed
Schizophrenia susceptibility genes converge on interlinked pathways related to g...
Schizophrenia susceptibility genes converge on interlinked pathways related to glutamatergic transmission and long-term potentiation, oxidative stress and oligodendrocyte viability.
Schizophr Res. 2006 Sep ;86(1-3):1-14. Epub 2006 Jul 13 .

PubMed
What are the differences in decisional balance and self-efficacy between Turkish...
What are the differences in decisional balance and self-efficacy between Turkish smokers in different stages of change?
Addict Behav. 2007 Apr ;32(4):836-49. Epub 2006 Jul 13 .

PubMed
Antibrain antibodies in children with autism and their unaffected siblings.
Antibrain antibodies in children with autism and their unaffected siblings.
J Neuroimmunol. 2006 Sep ;178(1-2):149-55. Epub 2006 Jul 13 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Effects of mianserin and fluoxetine on axonal regeneration of brain catecholamine neurons.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information