Am J Clin Nutr. 2006 Jun;83(6 Suppl):1494S-1498S.

Potential role of dietary n-3 fatty acids in the prevention of dementia and macular degeneration.

Source

Carotenoid & Health and Lipid Metabolism Laboratories, Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA. elizabeth.johnson@tufts.edu

Erratum in

Am J Clin Nutr. 2006 Dec;84(6):1555.

Abstract

Dementia and age-related macular degeneration (AMD) are major causes of disability in the elderly. n-3 Fatty acids, particularly docosahexaenoic acid (DHA), are highly concentrated in brain and retinal tissue and may prevent or delay the progression of dementia and AMD. Low dietary intakes and plasma concentrations have been reported to be associated with dementia, cognitive decline, and AMD risk. The major dietary sources of DHA are fish and fish oils, although dietary supplements are available. At this point, it is not possible to make firm recommendations regarding n-3 fatty acids and the prevention of dementia and AMD. Our own unpublished observations from the Framingham Heart Study suggest that > or =180 mg/d of dietary DHA (approximately 2.7 fish servings/wk) is associated with an approximately 50% reduction in dementia risk. At least this amount of DHA is generally found in one commercially available 1-g fish oil capsule given daily.

PMID:: 16841859; [PubMed - indexed for MEDLINE]

Free full text

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

HV-83-03/HV/NHLBI NIH HHS/United States

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Cigarette smoking, fish consumption, omega-3 fatty acid intake, and associations with age-related macular degeneration: the US Twin Study of Age-Related Macular Degeneration. [Arch Ophthalmol. 2006]
Cigarette smoking, fish consumption, omega-3 fatty acid intake, and associations with age-related macular degeneration: the US Twin Study of Age-Related Macular Degeneration.
Seddon JM, George S, Rosner B. Arch Ophthalmol. 2006 Jul; 124(7):995-1001.
Oily fish consumption, dietary docosahexaenoic acid and eicosapentaenoic acid intakes, and associations with neovascular age-related macular degeneration. [Am J Clin Nutr. 2008]
Oily fish consumption, dietary docosahexaenoic acid and eicosapentaenoic acid intakes, and associations with neovascular age-related macular degeneration.
Augood C, Chakravarthy U, Young I, Vioque J, de Jong PT, Bentham G, Rahu M, Seland J, Soubrane G, Tomazzoli L, et al. Am J Clin Nutr. 2008 Aug; 88(2):398-406.
Dietary fatty acids and the 10-year incidence of age-related macular degeneration: the Blue Mountains Eye Study. [Arch Ophthalmol. 2009]
Dietary fatty acids and the 10-year incidence of age-related macular degeneration: the Blue Mountains Eye Study.
Tan JS, Wang JJ, Flood V, Mitchell P. Arch Ophthalmol. 2009 May; 127(5):656-65.
Review Omega 3 fatty acids and the eye. [Insight. 2008]
Review Omega 3 fatty acids and the eye.
Cakiner-Egilmez T. Insight. 2008 Oct-Dec; 33(4):20-5; quiz 26-7.
Review PUFA for prevention and treatment of dementia? [Curr Pharm Des. 2009]
Review PUFA for prevention and treatment of dementia?
Carrié I, Abellan Van Kan G, Rolland Y, Gillette-Guyonnet S, Vellas B. Curr Pharm Des. 2009; 15(36):4173-85.

See reviews... See all...

Cited by 3 PubMed Central articles

Isolevuglandins covalently modify phosphatidylethanolamines in vivo: detection and quantitative analysis of hydroxylactam adducts. [Free Radic Biol Med. 2009]
Isolevuglandins covalently modify phosphatidylethanolamines in vivo: detection and quantitative analysis of hydroxylactam adducts.
Li W, Laird JM, Lu L, Roychowdhury S, Nagy LE, Zhou R, Crabb JW, Salomon RG. Free Radic Biol Med. 2009 Dec 1; 47(11):1539-52. Epub 2009 Sep 12.
Whole-body synthesis secretion of docosahexaenoic acid from circulating eicosapentaenoic acid in unanesthetized rats. [J Lipid Res. 2009]
Whole-body synthesis secretion of docosahexaenoic acid from circulating eicosapentaenoic acid in unanesthetized rats.
Gao F, Kiesewetter D, Chang L, Ma K, Rapoport SI, Igarashi M. J Lipid Res. 2009 Dec; 50(12):2463-70. Epub 2009 Jul 1.
Omega-3 fatty acid docosahexaenoic acid increases SorLA/LR11, a sorting protein with reduced expression in sporadic Alzheimer's disease (AD): relevance to AD prevention. [J Neurosci. 2007]
Omega-3 fatty acid docosahexaenoic acid increases SorLA/LR11, a sorting protein with reduced expression in sporadic Alzheimer's disease (AD): relevance to AD prevention.
Ma QL, Teter B, Ubeda OJ, Morihara T, Dhoot D, Nyby MD, Tuck ML, Frautschy SA, Cole GM. J Neurosci. 2007 Dec 26; 27(52):14299-307.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Potential role of dietary n-3 fatty acids in the prevention of dementia and macu...
Potential role of dietary n-3 fatty acids in the prevention of dementia and macular degeneration.
Am J Clin Nutr. 2006 Jun ;83(6 Suppl):1494S-1498S.

PubMed
n-3 fatty acids and cardiovascular disease.
n-3 fatty acids and cardiovascular disease.
Am J Clin Nutr. 2006 Jun ;83(6 Suppl):1477S-1482S.

PubMed
Regulation of gene expression by insulin and tumor necrosis factor alpha in 3T3-...
Regulation of gene expression by insulin and tumor necrosis factor alpha in 3T3-L1 cells. Modulation of the transcription of genes encoding acyl-CoA synthetase and stearoyl-CoA desaturase-1.
J Biol Chem. 1991 Dec 15 ;266(35):23525-8.

PubMed
Evaluation of the medial elbow in the throwing athlete.
Evaluation of the medial elbow in the throwing athlete.
Am J Orthop (Belle Mead NJ). 2006 Jun ;35(6):266-9.

PubMed
Bupropion extended release compared with escitalopram: effects on sexual functio...
Bupropion extended release compared with escitalopram: effects on sexual functioning and antidepressant efficacy in 2 randomized, double-blind, placebo-controlled studies.
J Clin Psychiatry. 2006 May ;67(5):736-46.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: