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J Epidemiol Community Health. 2006 Aug;60(8):683-5.

Assessing effects of disease genes and gene-environment interactions: the case-spouse design and the counterfactual-control analysis.

Author information

  • 1Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei. wenchung@ha.mc.ntu.edu.tw

Abstract

BACKGROUND:

Assessing joint genetic and environmental contributions to disease risk is the central issue in many genetic epidemiological studies. To characterise the effects of a gene, the case-control study may suffer from the problem of population stratification bias. For a late onset disease, recruiting control subjects into case-parents and case-sibling studies may be difficult.

METHODS:

Two novel approaches to analysing case-spouse data are introduced: the 1:1 case-counterfactual-control analysis (genotype swapping between the case and their spouse) and the 1:5 case-counterfactual-controls analysis (allele swapping).

RESULTS:

Both can be implemented using statistical packages that allow matched analysis (the conditional logistic regression) to yield valid estimates of the genotype relative risk, the gene-environment interaction parameter, the gene-sex interaction parameter, and the gene-environment-sex three factor interaction parameter (if desired), if certain assumptions are fulfilled.

CONCLUSION:

Because of the ease in recruiting subjects, and in collecting and analysing data, this approach makes a convenient tool for gene characterisation.

PMID:
16840757
[PubMed - indexed for MEDLINE]
PMCID:
PMC2588086
Free PMC Article
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