Cell. 2006 Jul 14;126(1):30-2.

p53 and metabolism: Inside the TIGAR.

Source

Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. douglas.green@stjude.org

Abstract

The p53 tumor suppressor pathway coordinates DNA repair, cell-cycle arrest, apoptosis, and senescence to preserve genomic stability and prevent tumor formation. The discovery of three new target genes for p53 reveals unexpected functions for this tumor suppressor in the regulation of glucose metabolism and autophagy.

Comment on

TIGAR, a p53-inducible regulator of glycolysis and apoptosis. [Cell. 2006]
TIGAR, a p53-inducible regulator of glycolysis and apoptosis.Bensaad K, Tsuruta A, Selak MA, Vidal MN, Nakano K, Bartrons R, Gottlieb E, Vousden KH. Cell. 2006 Jul 14; 126(1):107-20.
DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. [Cell. 2006]
DRAM, a p53-induced modulator of autophagy, is critical for apoptosis.Crighton D, Wilkinson S, O'Prey J, Syed N, Smith P, Harrison PR, Gasco M, Garrone O, Crook T, Ryan KM. Cell. 2006 Jul 14; 126(1):121-34.

PMID:: 16839873; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

Tumor Suppressor Protein p53

LinkOut - more resources

Full Text Sources

Other Literature Sources

Research Materials

Supplemental Content

Save items

Related citations in PubMed

TIGAR, a p53-inducible regulator of glycolysis and apoptosis. [Cell. 2006]
TIGAR, a p53-inducible regulator of glycolysis and apoptosis.
Bensaad K, Tsuruta A, Selak MA, Vidal MN, Nakano K, Bartrons R, Gottlieb E, Vousden KH. Cell. 2006 Jul 14; 126(1):107-20.
Review Regulation of glucose metabolism by p53: emerging new roles for the tumor suppressor. [Oncotarget. 2011]
Review Regulation of glucose metabolism by p53: emerging new roles for the tumor suppressor.
Madan E, Gogna R, Bhatt M, Pati U, Kuppusamy P, Mahdi AA. Oncotarget. 2011 Dec; 2(12):948-57.
p53: 25 years of research and more questions to answer. [Cell Death Differ. 2003]
p53: 25 years of research and more questions to answer.
Bourdon JC, Laurenzi VD, Melino G, Lane D. Cell Death Differ. 2003 Apr; 10(4):397-9.
p53 and TIGAR regulate cardiac myocyte energy homeostasis under hypoxic stress. [Am J Physiol Heart Circ Physio...]
p53 and TIGAR regulate cardiac myocyte energy homeostasis under hypoxic stress.
Kimata M, Matoba S, Iwai-Kanai E, Nakamura H, Hoshino A, Nakaoka M, Katamura M, Okawa Y, Mita Y, Okigaki M, et al. Am J Physiol Heart Circ Physiol. 2010 Dec; 299(6):H1908-16. Epub 2010 Oct 8.
Review Regulation of p53 responses by post-translational modifications. [Cell Death Differ. 2003]
Review Regulation of p53 responses by post-translational modifications.
Xu Y. Cell Death Differ. 2003 Apr; 10(4):400-3.

See reviews... See all...

Cited by 31 PubMed Central articles

Targeting metabolism to induce cell death in cancer cells and cancer stem cells. [Int J Cell Biol. 2013]
Targeting metabolism to induce cell death in cancer cells and cancer stem cells.
Pecqueur C, Oliver L, Oizel K, Lalier L, Vallette FM. Int J Cell Biol. 2013; 2013:805975. Epub 2013 Feb 12.
Expression of p53 in the effects of artesunate on induction of apoptosis and inhibition of proliferation in rat primary hepatic stellate cells. [PLoS One. 2011]
Expression of p53 in the effects of artesunate on induction of apoptosis and inhibition of proliferation in rat primary hepatic stellate cells.
Longxi P, Buwu F, Yuan W, Sinan G. PLoS One. 2011; 6(10):e26500. Epub 2011 Oct 28.
Regulation of p53 function by lysine methylation. [Epigenomics. 2011]
Regulation of p53 function by lysine methylation.
West LE, Gozani O. Epigenomics. 2011 Jun; 3(3):361-9.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide
Primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
Protein
Protein translation features of primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

p53 and metabolism: Inside the TIGAR.
p53 and metabolism: Inside the TIGAR.
Cell. 2006 Jul 14 ;126(1):30-2.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: