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Semin Cell Dev Biol. 2006 Apr;17(2):194-203. Epub 2006 May 26.

Planar cell polarity and vertebrate organogenesis.

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  • 1Department of Internal Medicine, Division of Nephrology, University of Texas, Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, 75390, USA.

Abstract

In addition to being polarized along their apical/basal axis, cells composing most (if not all) organs are also polarized in a plane vertical to the A/B axis. Recent studies indicate that this so-called planar cell polarity (PCP) plays an essential role in the formation of multiple organ systems regulating directed cell migrations, polarized cell division and proper differentiation. In this review we will discuss the molecular mechanisms regulating PCP, including the hypothesized roles for Wnt ligands in this process, and its roles in vertebrate organogenesis.

PMID:
16839790
[PubMed - indexed for MEDLINE]
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