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Lancet. 1991 Dec 14;338(8781):1488-90.

First-pass metabolism of cyclosporin by the gut.

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  • 1Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor.

Abstract

Cyclosporin is thought to be exclusively metabolised in the liver. We instilled cyclosporin into the small bowel of 2 patients during the anhepatic phase of liver transplantation; cyclosporin metabolites were readily detected in portal venous blood. Our findings indicate that the small intestine is a major site of cyclosporin breakdown: such intestinal metabolism might help to explain the poor oral bioavailability and drug interactions of cyclosporin.

PMID:
1683920
[PubMed - indexed for MEDLINE]
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