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    Cytogenet Cell Genet. 1991;57(4):187-92.

    Chromosomal localization of the human gene for annexin V (placental anticoagulant protein I) to 4q26----q28.

    Tait JF, Frankenberry DA, Shiang R, Murray JC, Adler DA, Disteche CM.

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    Department of Laboratory Medicine, University of Washington, Seattle 98195.

    Abstract

    Annexin V is a member of a new family of calcium-dependent phospholipid-binding proteins. It has been previously isolated as placental anticoagulant protein I, inhibitor of blood coagulation, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4, and anchorin CII. The human gene encoding annexin V (ANX5) was localized to 4q26----q28 by in situ hybridization with a cDNA probe and polymerase chain-reaction (PCR) analysis of a human x hamster hybrid cell panel. The regional localization to 4q26----q28 was supported by Southern-blot analysis of a human cell line with a deletion in 4q23----q27. This localization overlaps but differs slightly from the previous assignment of ANX5 to 4q28----q32. Digestion with PvuII and TaqI identified polymorphisms at the ANX5 locus; the PvuII polymorphism could also be detected by PCR analysis.

    PMID:
    1683830
    [PubMed - indexed for MEDLINE]

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